Validation of an equation predicting highly unsaturated fatty acid (HUFA) compositions of human blood fractions from dietary intakes of both HUFAs and their precursors

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 136; pp. 171 - 176
• Main Authors: Strandjord, Sarah E., Lands, Bill, Hibbeln, Joseph R.
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.09.2018
• Subjects: Advanced Basic Science; alpha-Linolenic Acid - blood; Blood lipids; Clinical Trials as Topic; Dietary Fats, Unsaturated - administration & dosage; Dietary Fats, Unsaturated - blood; Endocrinology & Metabolism; Fatty Acids, Omega-3 - blood; Fatty Acids, Omega-6 - blood; Fatty Acids, Unsaturated - administration & dosage; Fatty Acids, Unsaturated - blood; Highly unsaturated fatty acids (HUFA); HUFA balance; Humans; Linear Models; Linoleic Acid - blood; Models, Theoretical; Omega-3; Omega-6; NR; HUFA balance; S-PL; n-6 in HUFA; SDA; RBC; S-TL; n-3; n-6; RBC-PL; Blood lipids; Highly unsaturated fatty acids (HUFA); AA; PUFA; Omega-6; en; HUFA; Omega-3; EPA+DHA in RBC; P-TL; LA; ALA; EPA; DHA; P-PL; GLA; serum phospholipids; highly unsaturated fatty acids; plasma total lipids; polyunsaturated fatty acids; serum total lipids; red blood cell; omega-3; omega-6; docosahexaneoic acid; not reported; arachidonic acid; percentage of EPA and DHA in total fatty acids of red blood cell; alpha-linolenic acid; plasma phospholipids; percent of energy; linoleic acid; the percentage of omega-6 highly unsaturated fatty acids in total tissue HUFA; eicosapentaenoic acid; red blood cell phospholipids; stearidonic acid; gamma-linolenic acid

Proportions of omega-3 (n-3) and omega-6 (n-6) in 20- and 22-carbon highly unsaturated fatty acids with 3 or more double bonds (HUFA) accumulated in tissue HUFA (e.g., the %n-6 in HUFA) are biomarkers reflecting intakes of n-6 and n-3 fatty acids. An empirical equation, referred to here as the Lands...