In vitro-in vivo extrapolation of zolpidem as a perpetrator of metabolic interactions involving CYP3A - Polasek, Thomas M; Sadagopal, Janani S; Elliot, David J; Miners, John O (European journal of clinical pharmacology, 2010)
Keywords: Administration, Oral; Age Factors; Aged; Aged, 80 and over; Area Under Curve; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Computer Simulation; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System - metabolism; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors - pharmacology; Female; Humans; Liver - drug effects; Liver - enzymology; Male; Medical sciences; Metabolic Clearance Rate; Microsomes, Liver - enzymology; Midazolam - administration & dosage; Midazolam - pharmacokinetics; Models, Biological; Pharmacokinetics and Disposition; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pyridines - pharmacology; Recombinant Proteins - antagonists & inhibitors; Young Adult; Zolpidem; CYP3A; Zolpidem; Mechanism-based inactivation; Modelling and simulation; Drug-drug interactions; Midazolam; Cytochromes P450; In vitro-in vivo extrapolation; Agonist; Isozyme; Psychotropic; Benzodiazepine receptor; Inactivation; Imidazopyridine derivatives; Benzodiazepine derivatives; Drug interaction; Sedative; Mechanism of action; Human; Enzyme; Gabaergic agonist; Cytochrome P450; Hypnotic; Metabolism; In vitro; Extrapolation; In vivo; Simulation; Pharmacokinetics; Gabaergic receptor A