Combined delivery of BMP-2 and bFGF from nanostructured colloidal gelatin gels and its effect on bone regeneration in vivo

• Published in: Journal of controlled release Vol. 166; no. 2; pp. 172 - 181
• Main Authors: Wang, Huanan, Zou, Qin, Boerman, Otto C., Nijhuis, Arnold W.G., Jansen, John A., Li, Yubao, Leeuwenburgh, Sander C.G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.03.2013
• Subjects: adverse effects; Animals; biocompatibility; biocompatible materials; biodegradability; biomimetics; biopharmaceuticals; bone formation; Bone Morphogenetic Protein 2 - administration & dosage; Bone Morphogenetic Protein 2 - pharmacokinetics; Bone Morphogenetic Protein 2 - pharmacology; Bone Regeneration - drug effects; Colloidal gels; Colloids; Cross-Linking Reagents; crosslinking; Drug Carriers; Drug Stability; Dual growth factor; Femur - drug effects; Femur - growth & development; fibroblast growth factor 2; Fibroblast Growth Factor 2 - administration & dosage; Fibroblast Growth Factor 2 - pharmacokinetics; Fibroblast Growth Factor 2 - pharmacology; Gelatin; Gels; in vivo studies; Iodine Radioisotopes - chemistry; Isotope Labeling; Light; Male; monitoring; Nanospheres; Osteogenesis; Particle Size; radiolabeling; Rats; Rats, Sprague-Dawley; Rheology; Scattering, Radiation; Sequential release; tissue repair; X-Ray Microtomography; Sequential release; Nanospheres; Gelatin; Dual growth factor; Osteogenesis; Colloidal gels

During the process of bone regeneration, a multitude of morphogenetic signaling factors regulate cellular behavior and ultimately tissue response. These factors are presented to cells under strong spatial and temporal control, which stresses the relevance of controlled delivery of multiple growth fa...