Combined delivery of BMP-2 and bFGF from nanostructured colloidal gelatin gels and its effect on bone regeneration in vivo - Wang, Huanan; Zou, Qin; Boerman, Otto C.; Nijhuis, Arnold W.G.; Jansen, John A.; Li, Yubao; Leeuwenburgh, Sander C.G. (Journal of controlled release, 2013)
Keywords: adverse effects; Animals; biocompatibility; biocompatible materials; biodegradability; biomimetics; biopharmaceuticals; bone formation; Bone Morphogenetic Protein 2 - administration & dosage; Bone Morphogenetic Protein 2 - pharmacokinetics; Bone Morphogenetic Protein 2 - pharmacology; Bone Regeneration - drug effects; Colloidal gels; Colloids; Cross-Linking Reagents; crosslinking; Drug Carriers; Drug Stability; Dual growth factor; Femur - drug effects; Femur - growth & development; fibroblast growth factor 2; Fibroblast Growth Factor 2 - administration & dosage; Fibroblast Growth Factor 2 - pharmacokinetics; Fibroblast Growth Factor 2 - pharmacology; Gelatin; Gels; in vivo studies; Iodine Radioisotopes - chemistry; Isotope Labeling; Light; Male; monitoring; Nanospheres; Osteogenesis; Particle Size; radiolabeling; Rats; Rats, Sprague-Dawley; Rheology; Scattering, Radiation; Sequential release; tissue repair; X-Ray Microtomography; Sequential release; Nanospheres; Gelatin; Dual growth factor; Osteogenesis; Colloidal gels