Glucose-Induced Cyclic Lipopeptides Resistance in Bacteria via ATP Maintenance through Enhanced Glycolysis

• Published in: iScience Vol. 21; pp. 135 - 144
• Main Authors: Yu, Wen-Bang, Pan, Qian, Ye, Bang-Ce
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.11.2019; Elsevier
• Subjects: Microbial Metabolism; Microbiology; Molecular Mechanism of Behavior; Multi-Drug Resistant Organisms; Molecular Mechanism of Behavior; Microbiology; Microbial Metabolism; Multi-Drug Resistant Organisms

Cyclic lipopeptide (CLP) antibiotics have a mechanism that causes membrane malfunction. Thus mechanisms of bacterial resistance to CLPs are thought to modify cell surfaces. However, we found that bacterial resistance to CLPs was strongly related to energy metabolism. Using polymyxin B (PB) as a mode...