Components of the Rv0081-Rv0088 Locus, Which Encodes a Predicted Formate Hydrogenlyase Complex, Are Coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis

• Published in: Journal of Bacteriology Vol. 193; no. 19; pp. 5105 - 5118
• Main Authors: He, Hongjun, Bretl, Daniel J, Penoske, Renee M, Anderson, David M, Zahrt, Thomas C
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.10.2011
• Subjects: Antibiotics; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Binding sites; Biological and medical sciences; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Enzymes; etiological agents; Formate Dehydrogenases - genetics; Formate Dehydrogenases - metabolism; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation, Bacterial - genetics; Gene Expression Regulation, Bacterial - physiology; Gene Regulation; granuloma; loci; Microbiology; Miscellaneous; morbidity; mortality; Multienzyme Complexes - genetics; Multienzyme Complexes - metabolism; Mutation; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - metabolism; Nitric oxide; operon; Pathogens; promoter regions; Protamine Kinase - genetics; Protamine Kinase - metabolism; Protein Kinases - genetics; Protein Kinases - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal transduction; transcription factors; Tuberculosis; Hydrogenase; Mycobacterium tuberculosis; Enzyme; Mycobacteriales; Mycobacteriaceae; Bacteria; Formate; Actinomycetes; Oxidoreductases

Mycobacterium tuberculosis, the etiological agent of tuberculosis, remains a significant cause of morbidity and mortality throughout the world despite a vaccine and cost-effective antibiotics. The success of this organism can be attributed, in part, to its ability to adapt to potentially harmful str...