Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

• Published in: Cell metabolism Vol. 24; no. 6; pp. 795 - 806
• Main Authors: Mills, Kathryn F., Yoshida, Shohei, Stein, Liana R., Grozio, Alessia, Kubota, Shunsuke, Sasaki, Yo, Redpath, Philip, Migaud, Marie E., Apte, Rajendra S., Uchida, Koji, Yoshino, Jun, Imai, Shin-ichiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.12.2016
• Subjects: Administration, Oral; aging; Aging - drug effects; Aging - genetics; Aging - physiology; Animals; anti-aging; Bone Density - drug effects; Cell Respiration - drug effects; Darkness; Drinking - drug effects; Eating - drug effects; energy metabolism; Energy Metabolism - drug effects; eye function; Food; Gene Expression Regulation - drug effects; glucose metabolism; Insulin - pharmacology; insulin sensitivity; Lipids - blood; Lymphocytes - drug effects; Lymphocytes - metabolism; Male; Mice, Inbred C57BL; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Myeloid Cells - drug effects; Myeloid Cells - metabolism; NAD; NAD - metabolism; NAD+ precursor; nicotinamide mononucleotide; Nicotinamide Mononucleotide - administration & dosage; Nicotinamide Mononucleotide - blood; Nicotinamide Mononucleotide - pharmacology; NMN; Physical Conditioning, Animal; Time Factors; Weight Gain - drug effects; NAD; NAD+ precursor; insulin sensitivity; eye function; anti-aging; mitochondria; aging; nicotinamide mononucleotide; glucose metabolism; NMN; energy metabolism; NAD(+); NAD(+) precursor

NAD+ availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ biosynthesis and ameliorate various pathologies in mouse disease models. In this study, we conducted a 12-month-long NMN administration t...