Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice - Mills, Kathryn F.; Yoshida, Shohei; Stein, Liana R.; Grozio, Alessia; Kubota, Shunsuke; Sasaki, Yo; Redpath, Philip; Migaud, Marie E.; Apte, Rajendra S.; Uchida, Koji; Yoshino, Jun; Imai, Shin-ichiro (Cell metabolism, 2016)
Keywords: Administration, Oral; aging; Aging - drug effects; Aging - genetics; Aging - physiology; Animals; anti-aging; Bone Density - drug effects; Cell Respiration - drug effects; Darkness; Drinking - drug effects; Eating - drug effects; energy metabolism; Energy Metabolism - drug effects; eye function; Food; Gene Expression Regulation - drug effects; glucose metabolism; Insulin - pharmacology; insulin sensitivity; Lipids - blood; Lymphocytes - drug effects; Lymphocytes - metabolism; Male; Mice, Inbred C57BL; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Myeloid Cells - drug effects; Myeloid Cells - metabolism; NAD; NAD - metabolism; NAD+ precursor; nicotinamide mononucleotide; Nicotinamide Mononucleotide - administration & dosage; Nicotinamide Mononucleotide - blood; Nicotinamide Mononucleotide - pharmacology; NMN; Physical Conditioning, Animal; Time Factors; Weight Gain - drug effects; NAD; NAD+ precursor; insulin sensitivity; eye function; anti-aging; mitochondria; aging; nicotinamide mononucleotide; glucose metabolism; NMN; energy metabolism; NAD(+); NAD(+) precursor