A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation

• Published in: Blood Vol. 87; no. 3; pp. 983 - 992
• Main Authors: Lin, E Y, Orlofsky, A, Wang, H G, Reed, J C, Prystowsky, M B
• Format: Journal Article
• Language: English
• Published: United States 01.02.1996
• Subjects: Animals; Apoptosis - genetics; Base Sequence; Cell Differentiation - drug effects; Cell Differentiation - genetics; Cell Division - drug effects; Cell Line; Cell Line, Transformed; Chlorocebus aethiops; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Granulocyte Colony-Stimulating Factor - pharmacology; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - metabolism; Homeodomain Proteins; Interleukin-3 - pharmacology; Mice; Minor Histocompatibility Antigens; Molecular Sequence Data; Proto-Oncogene Proteins - physiology; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins - metabolism; Replication Protein C; Repressor Proteins; Saccharomyces cerevisiae Proteins; Transfection

A1, a bcl-2 family member, has been identified as a hematopoietic-specific, early inducible gene. In this study it is shown that stable transfection of A1 into an interleukin-3 (IL-3)-dependent myeloid precursor cell line, 32D c13, leads to a retardation of IL-3 withdrawal-induced cell death similar...