Antibody–drug conjugates: Recent advances in linker chemistry

• Published in: Acta pharmaceutica Sinica. B Vol. 11; no. 12; pp. 3889 - 3907
• Main Authors: Su, Zheng, Xiao, Dian, Xie, Fei, Liu, Lianqi, Wang, Yanming, Fan, Shiyong, Zhou, Xinbo, Li, Song
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021; Elsevier
• Subjects: Antibody–drug conjugate; Chemical trigger; Linker; Linker‒antibody attachment; Linker‒payload attachment; Review; Linker‒payload attachment; Antibody–drug conjugate; Linker‒antibody attachment; Linker; Chemical trigger

Antibody–drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody–drug conjugate linker molecule determines both the efficacy and the adverse effects, and so has a major influence on the fate of ADCs. An ideal linker should be stable in the circulatory system and re...