Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 141; no. 4; pp. 895 - 898
• Main Authors: Shimokawa, Hidehiko, MD, Uramoto, Hidetaka, MD, PhD, Onitsuka, Takamitsu, MD, PhD, Chundong, Gu, MD, PhD, Hanagiri, Takeshi, MD, PhD, Oyama, Tsunehiro, MD, PhD, Yasumoto, Kosei, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.04.2011; Elsevier
• Subjects: Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - mortality; Adenocarcinoma - secondary; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Biomarkers, Tumor - genetics; Cardiology. Vascular system; Cardiothoracic Surgery; Chi-Square Distribution; Colon cancer; copy number; Disease-Free Survival; Female; Humans; Japan; Kaplan-Meier Estimate; Lung Neoplasms - genetics; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Medical sciences; Metastases; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Non-small cell lung carcinoma; Odds Ratio; Pneumology; Pneumonectomy - adverse effects; Pneumonectomy - mortality; Polymerase chain reaction; Proportional Hazards Models; Reverse Transcriptase Polymerase Chain Reaction; Risk Assessment; Risk Factors; RNA, Messenger - analysis; Surgery; Survival; Thorax; Time Factors; Transcription Factors - genetics; Treatment Outcome; Tumors; Tumors of the respiratory system and mediastinum; Up-Regulation; Japan; DFS; 10.4; metastasis associated in colon cancer 1; colorectal cancer; disease-free survival; CRC; MACC1; PCR; polymerase chain reaction; Postoperative; Lung disease; Recurrence; Relapse; Respiratory disease; Malignant tumor; Bronchopulmonary adenocarcinoma; Messenger RNA; Bronchus disease; Anesthesia; Circulatory system; Cardiology; Cancer

Objective The purpose of this study was to clarify the role and clinical significance of metastasis associated in colon cancer 1 in resected stage I non–small cell lung cancers. Methods Tumor specimens were collected from 146 consecutive patients who underwent a complete resection for stage I lung a...