The SUMOylated METTL8 Induces R-loop and Tumorigenesis via m3C

• Published in: iScience Vol. 23; no. 3; p. 100968
• Main Authors: Zhang, Li-Hong, Zhang, Xue-Yun, Hu, Tao, Chen, Xin-Yun, Li, Jing-Jia, Raida, Manfred, Sun, Ning, Luo, Yan, Gao, Xiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.03.2020; Elsevier
• Subjects: Biological Sciences; Cancer; Molecular Biology; Molecular Mechanism of Gene Regulation; Molecular Structure; Biological Sciences; Molecular Structure; Molecular Biology; Molecular Mechanism of Gene Regulation; Cancer

R-loops, three-stranded DNA-DNA:RNA hybrid structures, are best known for their deleterious effects on genome stability. The regulatory factors of this fundamental genetic structure remain unclear. Here, we reveal an epigenetic factor that controls R-loop stability. METTL8, a member of the methyltra...