Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders

• Published in: Annals of neurology Vol. 56; no. 3; pp. 416 - 423
• Main Authors: Letendre, Scott L., McCutchan, J. Allen, Childers, Meredith E., Woods, Steven P., Lazzaretto, Deborah, Heaton, Robert K., Grant, Igor, Ellis, Ronald J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2004; Willey-Liss
• Subjects: Adult; Anti-Retroviral Agents - pharmacology; Anti-Retroviral Agents - therapeutic use; Biological and medical sciences; Chi-Square Distribution; Cognition Disorders - cerebrospinal fluid; Cognition Disorders - drug therapy; Cognition Disorders - psychology; Female; HIV Infections - drug therapy; HIV Infections - psychology; HIV-1 - drug effects; HIV-1 - metabolism; Human immunodeficiency virus; Humans; Male; Medical sciences; Middle Aged; Multivariate Analysis; Neurology; Neuropsychological Tests - statistics & numerical data; Prospective Studies; Statistics, Nonparametric; Virus; Nervous system diseases; Cognitive therapy; Treatment; Cognitive disorder; Retroviridae; Antiviral; Human immunodeficiency virus; Lentivirus

The benefits of combination antiretroviral therapy (ART) for HIV cognitive disorders vary substantially between individuals. This study evaluated whether cerebrospinal fluid (CSF) drug penetration and CSF virological suppression influence the extent of neuropsychological (NP) improvement during ART....