RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

• Published in: Nature communications Vol. 12; no. 1; pp. 1518 - 14
• Main Authors: Wang, Xia, Wang, Jin, Tsui, Yu-Man, Shi, Chaoran, Wang, Ying, Zhang, Xin, Yan, Qian, Chen, Miao, Jiang, Chen, Yuan, Yun-Fei, Wong, Chun-Ming, Liu, Ming, Feng, Zeng-yu, Chen, Honglin, Ng, Irene Oi Lin, Jiang, Lingxi, Guan, Xin-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/106; 13/109; 38/77; 38/90; 38/91; 631/67; 631/67/1504/1610; 82/80; AKT protein; Animals; Cancer; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell self-renewal; Chemoresistance; Embryo cells; Embryonic Stem Cells; Female; Gene Expression Regulation, Neoplastic; Hepatocellular carcinoma; Hepatocytes; Heterogeneous-Nuclear Ribonucleoprotein Group C - genetics; Heterogeneous-Nuclear Ribonucleoprotein Group C - metabolism; Humanities and Social Sciences; Humans; Liver; Liver - metabolism; Liver - pathology; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Metastases; Metastasis; Mice; Middle Aged; mRNA stability; multidisciplinary; N6-methyladenosine; Neoplastic Stem Cells - metabolism; Phenotypes; Phosphatidylinositol 3-Kinases - metabolism; Progenitor cells; RNA Stability - physiology; RNA-binding protein; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Science; Science (multidisciplinary); Signal Transduction - genetics; Stability; Stat3 protein; STAT3 Transcription Factor - metabolism; Stem cells; Transforming Growth Factor beta2 - metabolism; Tumorigenicity; Up-Regulation

Growing evidences suggest that cancer stem cells exhibit many molecular characteristics and phenotypes similar to their ancestral progenitor cells. In the present study, human embryonic stem cells are induced to differentiate into hepatocytes along hepatic lineages to mimic liver development in vitr...