RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2 - Wang, Xia; Wang, Jin; Tsui, Yu-Man; Shi, Chaoran; Wang, Ying; Zhang, Xin; Yan, Qian; Chen, Miao; Jiang, Chen; Yuan, Yun-Fei; Wong, Chun-Ming; Liu, Ming; et al. (Nature communications, 2021)
Keywords: 1-Phosphatidylinositol 3-kinase; 13/106; 13/109; 38/77; 38/90; 38/91; 631/67; 631/67/1504/1610; 82/80; AKT protein; Animals; Cancer; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell self-renewal; Chemoresistance; Embryo cells; Embryonic Stem Cells; Female; Gene Expression Regulation, Neoplastic; Hepatocellular carcinoma; Hepatocytes; Heterogeneous-Nuclear Ribonucleoprotein Group C - genetics; Heterogeneous-Nuclear Ribonucleoprotein Group C - metabolism; Humanities and Social Sciences; Humans; Liver; Liver - metabolism; Liver - pathology; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Metastases; Metastasis; Mice; Middle Aged; mRNA stability; multidisciplinary; N6-methyladenosine; Neoplastic Stem Cells - metabolism; Phenotypes; Phosphatidylinositol 3-Kinases - metabolism; Progenitor cells; RNA Stability - physiology; RNA-binding protein; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Science; Science (multidisciplinary); Signal Transduction - genetics; Stability; Stat3 protein; STAT3 Transcription Factor - metabolism; Stem cells; Transforming Growth Factor beta2 - metabolism; Tumorigenicity; Up-Regulation