Acute Reversal of Endothelial Dysfunction in the Elderly After Antioxidant Consumption

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 59; no. 4; pp. 818 - 824
• Main Authors: Wray, D. Walter, Nishiyama, Steven K., Harris, Ryan A., Zhao, Jia, McDaniel, John, Fjeldstad, Anette S., Witman, Melissa A.H., Ives, Stephen J., Barrett-OʼKeefe, Zachary, Richardson, Russell S.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.04.2012; Lippincott Williams & Wilkins
• Subjects: Administration, Oral; Adult; Aged; Aging - physiology; Antioxidants - administration & dosage; Antioxidants - pharmacology; Antioxidants - therapeutic use; Arterial hypertension. Arterial hypotension; Ascorbic Acid - administration & dosage; Ascorbic Acid - pharmacology; Ascorbic Acid - therapeutic use; Biological and medical sciences; Blood and lymphatic vessels; Blood Flow Velocity - drug effects; Blood Flow Velocity - physiology; Blood Pressure - drug effects; Blood Pressure - physiology; Blood vessels and receptors; Cardiology. Vascular system; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Free Radicals - blood; Fundamental and applied biological sciences. Psychology; Humans; Hyperemia - epidemiology; Hyperemia - prevention & control; Incidence; Male; Medical sciences; Thioctic Acid - administration & dosage; Thioctic Acid - pharmacology; Thioctic Acid - therapeutic use; Vasodilation - drug effects; Vasodilation - physiology; Vertebrates: cardiovascular system; Vitamin E - administration & dosage; Vitamin E - pharmacology; Vitamin E - therapeutic use; Human; Hypertension; NO; vascular function; Senescence; free radicals; Cardiovascular disease; aging; Antioxidant; Elderly; Free radical; Endothelium

Aging is associated with a pro-oxidant state and a decline in endothelial function. Whether acute, enteral antioxidant treatment can reverse this decrement in vascular function is not well known. Flow-mediated vasodilation and reactive hyperemia were evaluated after consumption of either placebo or...