Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence

• Published in: Molecular microbiology Vol. 60; no. 5; pp. 1109 - 1122
• Main Authors: Muñoz‐Elías, Ernesto J., Upton, Anna M., Cherian, Joseph, McKinney, John D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2006; Blackwell Science
• Subjects: Animals; Bacteria; Biological and medical sciences; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Carbon-Carbon Lyases - classification; Carbon-Carbon Lyases - genetics; Carbon-Carbon Lyases - metabolism; Cells, Cultured; Citrate (si)-Synthase - genetics; Citrate (si)-Synthase - metabolism; Citric Acid - chemistry; Citric Acid - metabolism; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Fatty acids; Female; Fundamental and applied biological sciences. Psychology; Fungi; Genes; Hydro-Lyases - genetics; Hydro-Lyases - metabolism; Isocitrate Lyase - classification; Isocitrate Lyase - genetics; Isocitrate Lyase - metabolism; Isoenzymes - classification; Isoenzymes - genetics; Isoenzymes - metabolism; Macrophages - cytology; Macrophages - metabolism; Male; Metabolism; Mice; Mice, Inbred C57BL; Microbiology; Molecular Sequence Data; Molecular Structure; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - physiology; Pathogens; Phylogeny; Propionates - metabolism; Microbiology; Mycobacterium tuberculosis; Mycobacteriales; Virulence; Mycobacteriaceae; Bacteria; Actinomycetes; Intracellular; Metabolism

Summary Growth of bacteria and fungi on fatty acid substrates requires the catabolic β‐oxidation cycle and the anaplerotic glyoxylate cycle. Propionyl‐CoA generated by β‐oxidation of odd‐chain fatty acids is metabolized via the methylcitrate cycle. Mycobacterium tuberculosis possesses homologues of...