Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats

• Published in: The Journal of physiology Vol. 587; no. 14; pp. 3729 - 3739
• Main Authors: Laye, Matthew J., Rector, R. Scott, Warner, Shana O., Naples, Scott P., Perretta, Aspen L., Uptergrove, Grace M., Laughlin, M. Harold, Thyfault, John P., Booth, Frank W., Ibdah, Jamal A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK The Physiological Society 15.07.2009; Blackwell Publishing Ltd; Blackwell Science Inc
• Subjects: Adaptation, Physiological; Animals; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Humans; Integrative; Intra-Abdominal Fat - physiopathology; Intra-Abdominal Fat - ultrastructure; Mitochondria - metabolism; Mitochondria - ultrastructure; Physical Conditioning, Animal - methods; Physical Exertion; Rats; Rats, Long-Evans; Volition

Using the hyperphagic, obese, Otsuka Long–Evans Tokushima Fatty (OLETF) rat, we sought to determine if progression to type 2 diabetes alters visceral white adipose tissue (WAT) mitochondrial content and if these changes are modified through prevention of type 2 diabetes with daily exercise. At 4 w...