Hypoxia and Placental Development

• Published in: Birth defects research Vol. 109; no. 17; p. 1309
• Main Authors: Soares, Michael J, Iqbal, Khursheed, Kozai, Keisuke
• Format: Journal Article
• Language: English
• Published: United States 16.10.2017
• Subjects: trophoblast cell invasion; hypoxia; placenta development; hypoxia inducible factor

Hemochorial placentation is orchestrated through highly regulated temporal and spatial decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell acquisition of specializations facilitating invasion and uterine spiral artery remodeling is a labile process, sensitive to the e...