Soluble Epoxide Hydrolase Is a Main Effector of Angiotensin II–Induced Hypertension

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 45; no. 4, Part 2 Suppl; pp. 759 - 765
• Main Authors: Jung, Oliver, Brandes, Ralf P, Kim, In-Hae, Schweda, Frank, Schmidt, Ronald, Hammock, Bruce D, Busse, Rudi, Fleming, Ingrid
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.04.2005
• Subjects: Adamantane - analogs & derivatives; Adamantane - pharmacology; Amides - pharmacology; Angiotensin II; Animals; Antihypertensive Agents - pharmacology; Blood Pressure - drug effects; Diuresis - drug effects; Epoxide Hydrolases - antagonists & inhibitors; Epoxide Hydrolases - chemistry; Epoxide Hydrolases - metabolism; Hydroxyeicosatetraenoic Acids - antagonists & inhibitors; Hypertension - chemically induced; Hypertension - etiology; Hypertension - physiopathology; In Vitro Techniques; Lauric Acids - pharmacology; Male; Mice; Mice, Inbred Strains; Natriuresis - drug effects; Renal Circulation - drug effects; Solubility; Sulfones - pharmacology; Vasoconstrictor Agents; Vasodilation - drug effects

The soluble epoxide hydrolase (sEH) metabolizes vasodilatory epoxyeicosatrienoic acids (EETs) to their di-hydroxy derivatives. We hypothesized that the metabolism of EETs by the sEH contributes to angiotensin II–induced hypertension and tested the effects of a water-soluble sEH inhibitor, 12-(3-adam...