Probing Genome-Scale Model Reveals Metabolic Capability and Essential Nutrients for Growth of Probiotic Limosilactobacillus reuteri KUB-AC5

• Published in: Biology (Basel, Switzerland) Vol. 11; no. 2; p. 294
• Main Authors: Namrak, Thanawat, Raethong, Nachon, Jatuponwiphat, Theeraphol, Nitisinprasert, Sunee, Vongsangnak, Wanwipa, Nakphaichit, Massalin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.02.2022; MDPI
• Subjects: Amino acids; Asparagine; Bacteria; Biomass; Biosynthesis; Carbon; Carbon sources; Cell culture; cost effectiveness; Food industry; Gene expression; genome-scale metabolic model; Genomes; Glucose; Glutamine; Laboratories; Lactic acid; Lactic acid bacteria; Lactose; Limosilactobacillus reuteri; Linear programming; Lipids; metabolic capability; Metabolism; Metabolites; Nutrients; Physiology; probiotic strain; Probiotics; Proteins; Salmonella; Simulation; Sucrose; transcriptome; Transcriptomes; Transcriptomics; urea cycle; vitamin B complex; United States > US; Japan; metabolic capability; probiotic strain; Limosilactobacillus reuteri; genome-scale metabolic model; nutrients

Limosilactobacillus reuteri KUB-AC5 displays the hallmark features of probiotic properties for food and feed industries. Optimization of cultivation condition for the industrial production is important to reach cell concentration and cost reduction. Considering the strain-specific growth physiology,...