A Randomization Permutation Test for Single Subject Mediation

• Published in: Evaluation & the health professions Vol. 45; no. 1; pp. 54 - 65
• Main Authors: MacKinnon, David P., Smyth, Heather L., Somers, Jennifer, Ho, Emily, Norget, Julia, Miočević, Milica
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.03.2022; SAGE PUBLICATIONS, INC
• Subjects: Clinical outcomes; Computer Simulation; Data analysis; Humans; Individual differences; Measurement; Mediation; Medical research; Precision medicine; Random Allocation; Research Design; Simulation; idiographic methods; active ingredients; mediating mechanisms; single subject; permutation tests

In response to the importance of individual-level effects, the purpose of this paper is to describe the new randomization permutation (RP) test for a mediation mechanism for a single subject. We extend seminal work on permutation tests for individual-level data by proposing a test for mediation for...