Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration - Scott, Gregory; Zetterberg, Henrik; Jolly, Amy; Cole, James H; De Simoni, Sara; Jenkins, Peter O; Feeney, Claire; Owen, David R; Lingford-Hughes, Anne; Howes, Oliver; Patel, Maneesh C; Goldstone, Anthony P; et al. (Brain (London, England : 1878), 2018)
Keywords: Adult; Aged; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - diagnostic imaging; Brain Injuries, Traumatic - drug therapy; Cognition Disorders - diagnostic imaging; Cognition Disorders - etiology; Cross-Sectional Studies; Female; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Microglia - drug effects; Microglia - pathology; Middle Aged; Minocycline - therapeutic use; Neurodegenerative Diseases - chemically induced; Neurodegenerative Diseases - etiology; Neurofilament Proteins - metabolism; Neuropsychological Tests; Neurosciences; Neurovetenskaper; Original; Positron-Emission Tomography; Pyrimidines - pharmacokinetics; Statistics, Nonparametric; Young Adult; traumatic brain injury; neurodegeneration; positron emission tomography; microglia; minocycline