Wild-Type PrP and a Mutant Associated with Prion Disease are Subject to Retrograde Transport and Proteasome Degradation - Ma, Jiyan; Lindquist, Susan (Proceedings of the National Academy of Sciences - PNAS, 2001)
Keywords: Antibodies; Base Sequence; Biological Sciences; Cell aggregates; Cell Line; COS cells; Cultured cells; Cysteine Endopeptidases - metabolism; Cysteine Proteinase Inhibitors - pharmacology; Cytoplasm; Disease; DNA Primers; Fluorescent Antibody Technique; Hydrolysis; Multienzyme Complexes - metabolism; Mutagenesis, Site-Directed; Neurons; Prion diseases; Prion Diseases - genetics; Prion Diseases - metabolism; Prions; Proteasome Endopeptidase Complex; Protein Transport; Proteins; PrPSc Proteins - genetics; PrPSc Proteins - metabolism; Transfection