Increased Glucose Transport–Phosphorylation and Muscle Glycogen Synthesis after Exercise Training in Insulin-Resistant Subjects

• Published in: The New England journal of medicine Vol. 335; no. 18; pp. 1357 - 1362
• Main Authors: Perseghin, Gianluca, Price, Thomas B, Petersen, Kitt Falk, Roden, Michael, Cline, Gary W, Gerow, Karynn, Rothman, Douglas L, Shulman, Gerald I
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 31.10.1996
• Subjects: Adult; Biological Transport, Active; Diabetes; Diabetes Mellitus, Type 2 - genetics; Exercise - physiology; Female; Glucose; Glucose - metabolism; Glucose Clamp Technique; Glucose-6-Phosphate - metabolism; Glycogen - biosynthesis; Humans; Insulin; Insulin - metabolism; Insulin resistance; Insulin Resistance - physiology; Insulin Secretion; Male; Muscle, Skeletal - metabolism; Phosphorylation; Physical Fitness - physiology
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199610313351804

First-degree relatives of patients with non-insulin-dependent diabetes mellitus (NIDDM) have a lifetime risk of diabetes of approximately 40 percent. 1 In these relatives, insulin resistance is the best predictor of the development of diabetes and probably plays an important part in its pathogenesis. 2 – 4 The most important site of peripheral insulin resistance is the skeletal muscle, and in this tissue there are several steps involved in insulin-mediated glucose uptake in which insulin resistance might occur (Figure 1). Previous studies using carbon-13 nuclear magnetic resonance ( 13 C NMR) spectroscopy to measure the glycogen content of muscle demonstrated that a defect in insulin-stimulated . . .