What constitutes an “animal model of osteoarthritis” – the need for consensus?

• Published in: Osteoarthritis and cartilage Vol. 20; no. 4; pp. 261 - 267
• Main Authors: Little, C.B, Zaki, S
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2012
• Subjects: Animal Experimentation - standards; Animal models; Animals; Arthritis, Experimental - etiology; Arthritis, Experimental - genetics; Humans; Mice; Mice, Transgenic; Osteoarthritis; Osteoarthritis - etiology; Osteoarthritis - genetics; Pain; Pain - etiology; Pain - genetics; Pathology; Practice Guidelines as Topic; Rheumatology; Species Specificity; Pathology; Animal models; Pain; Osteoarthritis

Summary Objective To review the use of animal models of osteoarthritis (OA) with regard to their utility for investigation of the mechanisms and regulation of structural pathology and pain. Methods PubMed searches were conducted using separate clusters of terms to retrieve articles on (i) models of...