Heme oxygenase-1 induction by the clinically used anesthetic Isoflurane protects rat livers from ischemia/reperfusion injury

• Published in: Annals of surgery Vol. 245; no. 6; pp. 931 - 942
• Main Authors: SCHMIDT, Rene, TRITSCHLER, Eva, HOETZEL, Alexander, LOOP, Torsten, HUMAR, Matjaz, HALVERSCHEID, Leonie, GEIGER, Klaus K, PANNEN, Benedikt H. J
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.06.2007
• Subjects: Analysis of Variance; Anesthetics - pharmacology; Animals; Biological and medical sciences; Blood Flow Velocity; Blotting, Northern; Blotting, Western; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Heme Oxygenase-1 - metabolism; Immunoenzyme Techniques; Isoflurane - pharmacology; Liver - blood supply; Liver - enzymology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Malondialdehyde - metabolism; Medical sciences; Microcirculation; Original; Other diseases. Semiology; Rats; Rats, Sprague-Dawley; Reperfusion Injury - enzymology; Reperfusion Injury - prevention & control; Volatile compound; Rat; Enzyme; Induction; Use; Rodentia; Heme oxygenase (decyclizing); Hepatic ischemic reperfusion injury; Cardiovascular disease; Hepatic disease; Isoflurane; Vascular disease; Medicine; Vertebrata; Mammalia; Treatment; General anesthetic; Animal; Surgery; Digestive diseases; Oxidoreductases; Protection; Halogen Organic compounds

It was the aim of this study to characterize the influence of isoflurane-induced heme oxygenase-1 (HO-1) expression on hepatocellular integrity after ischemia and reperfusion. Abundant experimental data characterize HO-1 as one of the most powerful inducible enzymes that contribute to the protection...