Muscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock - Wang, Zhen; Li, Mingyi; Liu, Lu; Geng, Bin (Pharmacological reports, 2019)
Keywords: Animals; Atropine - pharmacology; Cholinergic anti-inflammatory pathway; Cytokines - metabolism; Drug Safety and Pharmacovigilance; Inflammation; Lipopolysaccharides; Liver - pathology; Lung - pathology; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Muscarinic cholinergic receptor; Neutrophil Infiltration - drug effects; Original Article; Pharmacotherapy; Pharmacy; Pirenzepine - analogs & derivatives; Pirenzepine - pharmacology; Receptor, Muscarinic M1 - antagonists & inhibitors; Receptor, Muscarinic M1 - physiology; Receptor, Muscarinic M2 - antagonists & inhibitors; Receptor, Muscarinic M2 - physiology; Sepsis; Shock, Septic - chemically induced; Shock, Septic - drug therapy; Shock, Septic - mortality; Shock, Septic - physiopathology; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - metabolism; Muscarinic cholinergic receptor; Sepsis; Inflammation; Cholinergic anti-inflammatory pathway