Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells

• Published in: Cell death & disease Vol. 1; no. 9; p. e75
• Main Authors: Flourakis, M, Lehen'kyi, V, Beck, B, Raphaël, M, Vandenberghe, M, Abeele, F V, Roudbaraki, M, Lepage, G, Mauroy, B, Romanin, C, Shuba, Y, Skryma, R, Prevarskaya, N
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2010; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/45/269/1146; 631/80/304; 631/80/82/23; 692/699/67/589/466; Amino Acid Substitution; Antibodies; Antineoplastic Agents - therapeutic use; Apoptosis; Biochemistry; Biomedical and Life Sciences; Calcium - metabolism; Calcium Channels - genetics; Calcium Channels - metabolism; Calcium Channels - physiology; Cell Biology; Cell Culture; Cell Line, Tumor; Cisplatin - therapeutic use; Humans; Immunology; Life Sciences; Male; Membrane Proteins - metabolism; Mutation; Neoplasm Proteins - metabolism; ORAI1 Protein; Original; original-article; Phenotype; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - metabolism; Stromal Interaction Molecule 1; Thapsigargin - therapeutic use; Tumor Necrosis Factor-alpha - therapeutic use; prostate cancer; apoptosis resistance; Orai channels; store-operated calcium entry

The molecular nature of calcium (Ca 2+ )-dependent mechanisms and the ion channels having a major role in the apoptosis of cancer cells remain a subject of debate. Here, we show that the recently identified Orai1 protein represents the major molecular component of endogenous store-operated Ca 2+ ent...