MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma

• Published in: Oncogene Vol. 32; no. 3; pp. 277 - 285
• Main Authors: Boll, K, Reiche, K, Kasack, K, Mörbt, N, Kretzschmar, A K, Tomm, J M, Verhaegh, G, Schalken, J, von Bergen, M, Horn, F, Hackermüller, J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.01.2013; Nature Publishing Group
• Subjects: 631/337/384/331; 631/80/86; 692/420/755; 692/699/67/589/466; Androgen receptors; Androgens; Apoptosis; Apoptosis - genetics; Argonaute 2 protein; Argonaute Proteins - metabolism; Cancer; Castration; Cell Biology; Cell cycle; Cell Cycle Checkpoints - genetics; Cell Line, Tumor; Cell Proliferation; Development and progression; Down-Regulation - genetics; Genes, Reporter - genetics; Genetic aspects; Health aspects; Human Genetics; Humans; Internal Medicine; Male; MAP kinase; MAP Kinase Signaling System - genetics; Medicine; Medicine & Public Health; MicroRNA; MicroRNAs - genetics; miRNA; Oncogenes; Oncogenes - genetics; Oncology; original-article; Physiological aspects; Prostate cancer; prostate carcinoma; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Proto-Oncogene Proteins p21(ras) - metabolism; Receptors, Androgen - metabolism; Sarcoma; Signal transduction; Signal Transduction - genetics; Transfer RNA; Tumor cells; Tumor suppressor genes; Tumors; Western blotting; United States; United States > US; microRNAs; MAPK pathway; androgen receptor signaling; prostate carcinoma; microRNA targets

With ∼30 000 deaths annually in the United States, prostate cancer (PCa) is a major oncologic disease. Here we show that the microRNAs miR-130a, miR-203 and miR-205 jointly interfere with the two major oncogenic pathways in prostate carcinoma and are downregulated in cancer tissue. Using transcripto...