Y-box binding protein 1 (YB-1) promotes detection of DNA bulky lesions by XPC-HR23B factor

• Published in: Biochemistry (Moscow) Vol. 80; no. 2; pp. 219 - 227
• Main Authors: Fomina, E. E., Pestryakov, P. E., Maltseva, E. A., Petruseva, I. O., Kretov, D. A., Ovchinnikov, L. P., Lavrik, O. I.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.02.2015; Springer; Springer Nature B.V
• Subjects: Binding sites; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA Adducts - metabolism; DNA binding proteins; DNA Repair; DNA Repair Enzymes - metabolism; DNA-Binding Proteins - metabolism; Environmental factors; Health aspects; Humans; Lesions; Life Sciences; Medical treatment; Microbiology; Polycyclic aromatic hydrocarbons; Protein research; Proteins; Substrate Specificity; Ultraviolet radiation; Y-Box-Binding Protein 1 - metabolism; DNA-protein complexes; XPC-HR23B; clustered DNA lesions; bulky DNA lesions; Y-box binding protein 1 (YB-1); nucleotide excision repair

The nucleotide excision repair system (NER) is one of the main mechanisms protecting cellular DNA from lesions caused by such significant environmental factors as UV radiation, the influence of polycyclic aromatic hydrocarbons, and medical treatment by several antitumor drugs, e.g. cisplatin. One of...