Chronic ethanol consumption does not affect action of propofol on rat hippocampal acetylcholine release in vivo

• Published in: British journal of anaesthesia : BJA Vol. 93; no. 5; pp. 737 - 739
• Main Authors: Inagawa, G., Sato, K., Kikuchi, T., Nishihama, M., Shioda, M., Koyama, Y., Yamada, Y., Andoh, T.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.11.2004; Oxford University Press; Oxford Publishing Limited (England)
• Subjects: Acetylcholine - secretion; Alcoholism - metabolism; anaesthetics i.v; anaesthetics i.v., propofol; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Intravenous - pharmacology; Animals; Biological and medical sciences; brain; brain, hippocampus; Chromatography, High Pressure Liquid; Disease Models, Animal; ethanol; Ethanol - pharmacology; hippocampus; Hippocampus - drug effects; Hippocampus - secretion; Male; Medical sciences; model, rat; pharmacology; pharmacology, ethanol; propofol; Propofol - pharmacology; rat; Rats; Rats, Sprague-Dawley; anaesthetics i.v., propofol; brain, hippocampus; model, rat; pharmacology, ethanol; Ethanol; Rat; hippocampus; model; Rodentia; HPLC chromatography; Medical screening; Tap water; Encephalon; Vertebrata; Chronic; Mammalia; Microdialysis; Sleep; anaesthetics i.v; General anesthetic; rat; pharmacology; Animal; Neurotransmitter; Anesthesia; Acetylcholine; Propofol; propofol; brain; Hippocampus

The aim of this study was to examine ethanol-consumption-related changes in the effects of propofol on rat hippocampal acetylcholine (ACh) release. Male Sprague–Dawley rats received a solution of ethanol (20% v/v) for 24 weeks while controls received tap water. The effects of propofol were examined...