Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?

• Published in: Cancer discovery Vol. 11; no. 10; pp. 2396 - 2412
• Main Authors: Derosa, Lisa, Routy, Bertrand, Desilets, Antoine, Daillère, Romain, Terrisse, Safae, Kroemer, Guido, Zitvogel, Laurence
• Format: Journal Article
• Language: English
• Published: United States 01.10.2021
• Subjects: Gastrointestinal Microbiome; Humans; Immunotherapy - trends; Medicin och hälsovetenskap; Microbiota; Neoplasms

The cancer-immune dialogue subject to immuno-oncological intervention is profoundly influenced by microenvironmental factors. Indeed, the mucosal microbiota-and more specifically, the intestinal ecosystem-influences the tone of anticancer immune responses and the clinical benefit of immunotherapy. A...