Synergistic effect of glucocorticoids and androgens on the hormonal induction of tissue plasminogen activator activity and messenger ribonucleic acid levels in granulosa cells

• Published in: Molecular and cellular endocrinology Vol. 68; no. 2; pp. 143 - 151
• Main Authors: Xiao-Chi, Jia, Tor, Ny, Hsueh, Aaron J.W.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 1990; Elsevier
• Subjects: Androgen; Animals; Biological and medical sciences; Drug Synergism; Female; Fundamental and applied biological sciences. Psychology; Glucocorticoid; Glucocorticoids - administration & dosage; Granulosa cell, ovary; Granulosa Cells - drug effects; Granulosa Cells - metabolism; Hormonal induction; Hormone metabolism and regulation; In Vitro Techniques; Mammalian female genital system; mRNA; Plasminogen activator activity; Protein Kinases - metabolism; Rats; Rats, Inbred Strains; RNA, Messenger - metabolism; Synergism; Testosterone Congeners - administration & dosage; Tissue Plasminogen Activator - biosynthesis; Tissue Plasminogen Activator - metabolism; Vertebrates: reproduction; Androgen; Plasminogen activator activity; Granulosa cell, ovary; mRNA; Glucocorticoid; Synergism; Hormonal induction; Cell culture; Rat; Enzyme; Rodentia; Gonadotropin RH; Plasminogen activator; Gene expression; Northern blotting; Ovary; Vertebrata; Mammalia; Epidermal growth factor; Messenger RNA; Enzymatic activity; Protein kinase; Female genital system; FSH; Granulosa; Sex steroid hormone

Tissue-type plasminogen activator (tPA) is secreted by rat granulosa cells m response to treatment with activators of protein kinase A (follitropin, FSH), protein kinase C (gonadotropin-releasing hormone, GnRH) and tyrosine kinase (epidermal growth factor, EGF). Because steroid hormones have been sh...