Peptidomic discovery of short open reading frame–encoded peptides in human cells

• Published in: Nature chemical biology Vol. 9; no. 1; pp. 59 - 64
• Main Authors: Slavoff, Sarah A, Mitchell, Andrew J, Schwaid, Adam G, Cabili, Moran N, Ma, Jiao, Levin, Joshua Z, Karger, Amir D, Budnik, Bogdan A, Rinn, John L, Saghatelian, Alan
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2013; Nature Publishing Group
• Subjects: 631/208/726/1912; 631/92/475; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Cell Biology; Cellular biology; Chemistry; Chemistry/Food Science; Codon; Humans; Mammals; Open Reading Frames; Peptides; Peptides - chemistry; Polypeptides; Proteome; Proteomics; RNA, Messenger - genetics

The human genome contains stretches of DNA sequence with unknown function. Peptidomics coupled to RNA-Seq now reveals a class of short open reading frames in human genomes that are translated into small peptides. The complete extent to which the human genome is translated into polypeptides is of fun...