Major signaling pathways in intestinal stem cells

• Published in: Biochimica et biophysica acta Vol. 1830; no. 2; pp. 2410 - 2426
• Main Authors: Vanuytsel, Tim, Senger, Stefania, Fasano, Alessio, Shea-Donohue, Terez
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2013
• Subjects: animal models; Animals; Bmp; celiac disease; cells; Hedgehog; Hippo; homeostasis; humans; Intestinal stem cell; Intestines - cytology; Intestines - metabolism; Mice; Notch; pathogenesis; Signal Transduction; stem cells; Stem Cells - cytology; Stem Cells - metabolism; transgenic animals; Wnt; CD; GI; KO; Bmp; CBC; DSS; Hippo; Notch; SMC; IBD; UC; bHLH; Hedgehog; FAP; SNP; ISC; Intestinal stem cell; LRC; GSI; Wnt; BrdU; ISEMF

The discovery of markers to identify the intestinal stem cell population and the generation of powerful transgenic mouse models to study stem cell physiology have led to seminal discoveries in stem cell biology. In this review we give an overview of the current knowledge in the field of intestinal s...