A High Level of Cyclooxygenase-2 Inhibitor Selectivity is Associated with a Reduced Interference of Platelet Cyclooxygenase-1 Inactivation by Aspirin - Ouellet, Marc; Riendeau, Denis; Percival, M. David (Proceedings of the National Academy of Sciences - PNAS, 2001)
Keywords: Acetylation; Active sites; Animals; Anti-inflammatory agents; Anticoagulants; Aspirin; Aspirin - pharmacology; Biological Sciences; Blood Platelets - drug effects; Blood Platelets - enzymology; Calcium; Celecoxib; Cellular biology; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase inhibitors; Cyclooxygenase Inhibitors - pharmacology; Dosage; Drug therapy; Etoricoxib; Gels; Humans; Ibuprofen - pharmacology; In Vitro Techniques; Inactivation; Inhibitory concentration 50; Isoenzymes - antagonists & inhibitors; Isoenzymes - blood; Isoenzymes - chemistry; Isoxazoles - pharmacology; Lactones - pharmacology; Medical research; Membrane Proteins; Nonsteroidal anti-inflammatory drugs; Platelets; Prostaglandin-Endoperoxide Synthases - blood; Prostaglandin-Endoperoxide Synthases - chemistry; Pyrazoles; Pyridines - pharmacology; rofecoxib; Sheep; Sulfonamides - pharmacology; Sulfones - pharmacology; Titration