The Protective Role of Vitamin E against Oxidative Stress and Immunosuppression Induced by Non-Esterified Fatty Acids in Bovine Peripheral Blood Leukocytes

• Published in: Animals (Basel) Vol. 14; no. 7; p. 1079
• Main Authors: Li, Cheng-Yan, Lin, Wei-Chen, Moonmanee, Tossapol, Chan, Jacky Peng-Wen, Wang, Chien-Kai
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Blood; cattle; colony-stimulating factors; Cytokines; Dairy cattle; diet; Disease susceptibility; Ethylenediaminetetraacetic acid; Fatty acids; Granulocytes; Health risk assessment; Health risks; immunosuppression; Immunotherapy; Leukocytes; malondialdehyde; negative energy balance (NEB); Neutrophils; non-esterified fatty acids (NEFA); Oxidative stress; Penicillin; peripheral blood leukocytes; phagocytosis; Plasma; pro-inflammatory; protective effect; reactive oxygen species; Selenium; Vitamin E; St Louis Missouri; New York; United States > US; negative energy balance (NEB); non-esterified fatty acids (NEFA); peripheral blood leukocytes; transition period; vitamin E; oxidative stress; pro-inflammatory

High levels of non-esterified fatty acids (NEFAs) during the transition period lead to increased oxidative stress and immunosuppression in cows. Feeding them a vitamin-E-supplemented diet reduces reactive oxygen species (ROS) levels in the blood and diminishes immunosuppression in the transition per...