Clinical utility and predictive value of cerebrospinal fluid cell-free DNA profiling in non-small cell lung cancer patients with leptomeningeal metastasis

• Published in: Neoplasia (New York, N.Y.) Vol. 60; p. 101113
• Main Authors: Liang, Sheng-Kai, Liao, Wei-Yu, Shih, Jin-Yuan, Hsu, Chia-Lin, Yang, Ching-Yao, Wu, Shang-Gin, Lin, Yen-Ting, Wen, Yueh-Feng, Chen, Lun-Che, Chen, Yen-Fu, Chen, Ya-Fang, Lin, Yen-Heng, Yu, Chong-Jen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2025; Neoplasia Press; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - cerebrospinal fluid; Biomarkers, Tumor - genetics; Carcinoma, Non-Small-Cell Lung - cerebrospinal fluid; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell-free DNA (cfDNA); Cell-Free Nucleic Acids - cerebrospinal fluid; Cell-Free Nucleic Acids - genetics; Cerebrospinal fluid (CSF); ErbB Receptors - genetics; Female; High-Throughput Nucleotide Sequencing; Humans; Intrathecal pemetrexed; Leptomeningeal metastasis; Lung Neoplasms - cerebrospinal fluid; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Meningeal Carcinomatosis - cerebrospinal fluid; Meningeal Carcinomatosis - drug therapy; Meningeal Carcinomatosis - genetics; Meningeal Carcinomatosis - secondary; Meningeal Neoplasms - cerebrospinal fluid; Meningeal Neoplasms - drug therapy; Meningeal Neoplasms - genetics; Meningeal Neoplasms - secondary; Middle Aged; Mutation; Non-small cell lung cancer (NSCLC); Original Research; Predictive Value of Tests; Prognosis; LM; MSI; ITP; NSCLC; OS; MRI; TTD; CI; TMB; CNV; 19DEL; EGFR; Cerebrospinal fluid (CSF); Intrathecal pemetrexed; cfDNA; Non-small cell lung cancer (NSCLC); CSF; Leptomeningeal metastasis; ITC; Cell-free DNA (cfDNA); SNV; VAF; NGS

•CSF cfDNA sequencing reveals LM resistance mechanisms & treatment avenues in NSCLC.•ITP shows promise for post-targeted treatment NSCLC patients with LM.•MET copy number gain predicts beyond 6-month survival post-ITP in LM NSCLC cases. Leptomeningeal metastasis (LM) is a challenging complicatio...