Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease

• Published in: Neurotherapeutics Vol. 16; no. 1; pp. 192 - 202
• Main Authors: Cardoso, Barbara R., Roberts, Blaine R., Malpas, Charles B., Vivash, Lucy, Genc, Sila, Saling, Michael M., Desmond, Patricia, Steward, Christopher, Hicks, Rodney J., Callahan, Jason, Brodtmann, Amy, Collins, Steven, Macfarlane, Stephen, Corcoran, Niall M, Hovens, Christopher M., Velakoulis, Dennis, O'Brien, Terence J., Hare, Dominic J., Bush, Ashley I.
• Format: Journal Article
• Language: English
• Published: Cham Elsevier Inc 01.01.2019; Springer International Publishing; Springer Nature B.V
• Subjects: Aged; Alzheimer Disease - blood; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - drug therapy; Alzheimer's disease; Antioxidants; Antioxidants - administration & dosage; Antioxidants - metabolism; Biomedical and Life Sciences; Biomedicine; Central nervous system; Central Nervous System - drug effects; Central Nervous System - metabolism; Cerebrospinal fluid; Clinical trials; Cognitive ability; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Middle Aged; Nervous system; Neurobiology; Neurodegeneration; Neurology; Neurosciences; Neurosurgery; Original; Original Article; Pilot Projects; randomized controlled trial; Selenic Acid - administration & dosage; Selenic Acid - blood; Selenic Acid - cerebrospinal fluid; Selenium; Selenium - administration & dosage; Selenium - blood; Selenium - cerebrospinal fluid; Selenoproteins; Sodium; Sodium selenate; supranutritional selenium supplementation; Trace Elements - administration & dosage; Trace Elements - blood; Trace Elements - cerebrospinal fluid; Sodium selenate; selenium; supranutritional selenium supplementation; Alzheimer's disease; randomized controlled trial; Alzheimer’s disease

Insufficient supply of selenium to antioxidant enzymes in the brain may contribute to Alzheimer's disease (AD) pathophysiology; therefore, oral supplementation may potentially slow neurodegeneration. We examined selenium and selenoproteins in serum and cerebrospinal fluid (CSF) from a dual-dose...