Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes

• Published in: Biochimica et biophysica acta Vol. 1830; no. 4; pp. 2981 - 2988
• Main Authors: Ku, Chai Siah, Pham, Tho X., Park, Youngki, Kim, Bohkyung, Shin, Min Sun, Kang, Insoo, Lee, Jiyoung
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2013
• Subjects: acetylation; Active Transport, Cell Nucleus; Animals; Anti-inflammation; anti-inflammatory activity; apolipoprotein E; Arthrospira platensis; atherosclerosis; Blue-green algae; Cells, Cultured; Cyanobacteria - physiology; Cytokine array; Cytokines - biosynthesis; diet; epigenetics; gene expression; gene expression regulation; histone deacetylase; Histone Deacetylases - physiology; Histone deacetylation; histones; Histones - metabolism; inflammation; insulin resistance; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; Macrophages - immunology; messenger RNA; Mice; Mice, Inbred C57BL; NF-kappa B - antagonists & inhibitors; NF-κB; Nostoc commune; RAW 264.7 macrophage; secretion; Spirulina platensis; Spleen - cytology; splenocytes; transcription factor NF-kappa B; tumor necrosis factor-alpha; RAW 264.7 macrophage; NO; TNFα; Blue-green algae; apoE; SPE; LPS; Anti-inflammation; CBP; NF-κB; CREB; NLS; Histone deacetylation; BGA; SP; C-PC; BMM; IL; TSA; NOE; IκBα; CVD; HAT; Cytokine array; HDAC

Chronic inflammation contributes to the development of pathological disorders including insulin resistance and atherosclerosis. Identification of anti-inflammatory natural products can prevent the inflammatory diseases. Anti-inflammatory effects of blue-green algae (BGA), i.e., Nostoc commune var. s...