Bioreactors to influence stem cell fate: Augmentation of mesenchymal stem cell signaling pathways via dynamic culture systems

• Published in: Biochimica et biophysica acta Vol. 1830; no. 2; pp. 2470 - 2480
• Main Authors: Yeatts, Andrew B., Choquette, Daniel T., Fisher, John P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2013
• Subjects: Bioreactor; Bioreactors; cartilage; cell differentiation; Cell Lineage; Cell signaling; chondrocytes; Culture Media; dynamics; in vitro culture; Mesenchymal stem cell; osteoblasts; oxygen; Oxygen tension; Shear; shear stress; signal transduction; signals; stem cells; Stem Cells - cytology; Stem Cells - metabolism; tissue engineering; Mesenchymal stem cell; Bioreactor; Shear; Oxygen tension; Cell signaling

Mesenchymal stem cells (MSCs) are a promising cell source for bone and cartilage tissue engineering as they can be easily isolated from the body and differentiated into osteoblasts and chondrocytes. A cell based tissue engineering strategy using MSCs often involves the culture of these cells on thre...