Candidate Serological Biomarkers for Cancer Identified from the Secretomes of 23 Cancer Cell Lines and the Human Protein Atlas

• Published in: Molecular & cellular proteomics Vol. 9; no. 6; pp. 1100 - 1117
• Main Authors: Wu, Chih-Ching, Hsu, Chia-Wei, Chen, Chi-De, Yu, Chia-Jung, Chang, Kai-Ping, Tai, Dar-In, Liu, Hao-Ping, Su, Wen-Hui, Chang, Yu-Sun, Yu, Jau-Song
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2010; The American Society for Biochemistry and Molecular Biology
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - blood; Cathepsins - blood; Cell Differentiation; Cell Line, Tumor; Chemokine CXCL12 - blood; Cluster Analysis; Cytokines - blood; Electrophoresis, Polyacrylamide Gel; Female; Humans; Lipopolysaccharide Receptors - blood; Male; Middle Aged; Monocytes - cytology; Neoplasm Proteins - blood; Neoplasm Proteins - metabolism; Neoplasms - blood; Neoplasms - metabolism; Proteomics; Reproducibility of Results; Signal Transduction; Ubiquitins - blood; Young Adult

Although cancer cell secretome profiling is a promising strategy used to identify potential body fluid-accessible cancer biomarkers, questions remain regarding the depth to which the cancer cell secretome can be mined and the efficiency with which researchers can select useful candidates from the gr...