Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid

• Published in: Biochimica et biophysica acta Vol. 1830; no. 6; pp. 3447 - 3453
• Main Authors: Liu, Li, Hitchens, T. Kevin, Ye, Qing, Wu, Yijen, Barbe, Brent, Prior, Devin E., Li, Wendy F., Yeh, Fang-Cheng, Foley, Lesley M., Bain, Daniel J., Ho, Chien
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2013
• Subjects: Animals; bioavailability; Biological Availability; biosensors; blood circulation; Blood half-life; Contrast Media - pharmacokinetics; Contrast Media - pharmacology; drug delivery systems; drugs; Emulsions - pharmacokinetics; Emulsions - pharmacology; Fat Emulsions, Intravenous - pharmacokinetics; Fat Emulsions, Intravenous - pharmacology; Ferric Compounds - pharmacokinetics; Ferric Compounds - pharmacology; flow cytometry; Half-Life; hepatocytes; histology; image analysis; Intralipid; intravenous injection; iron; iron oxides; Kupffer cells; Kupffer Cells - cytology; Kupffer Cells - metabolism; Labeling of immune cells; liver; Liver - cytology; Liver - metabolism; magnetic resonance imaging; Magnetite Nanoparticles; Male; monocytes; Nanoparticles; Phospholipids - pharmacokinetics; Phospholipids - pharmacology; pretreatment; Rats; Rats, Inbred BN; RES clearance; Soybean Oil - pharmacokinetics; Soybean Oil - pharmacology; PBS; r2; RES; Intralipid; FDA; MRI; Blood half-life; BN; ppm; USPIO; MPIO; RES clearance; Nanoparticles; FITC; PEG; ICP-MS; Labeling of immune cells

Superparamagnetic iron-oxide nanoparticles are useful as contrast agents for anatomical, functional and cellular MRI, drug delivery agents, and diagnostic biosensors. Nanoparticles are generally cleared by the reticuloendothelial system (RES), in particular taken up by Kupffer cells in the liver, li...