Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid - Liu, Li; Hitchens, T. Kevin; Ye, Qing; Wu, Yijen; Barbe, Brent; Prior, Devin E.; Li, Wendy F.; Yeh, Fang-Cheng; Foley, Lesley M.; Bain, Daniel J.; Ho, Chien (Biochimica et biophysica acta, 2013)
Keywords: Animals; bioavailability; Biological Availability; biosensors; blood circulation; Blood half-life; Contrast Media - pharmacokinetics; Contrast Media - pharmacology; drug delivery systems; drugs; Emulsions - pharmacokinetics; Emulsions - pharmacology; Fat Emulsions, Intravenous - pharmacokinetics; Fat Emulsions, Intravenous - pharmacology; Ferric Compounds - pharmacokinetics; Ferric Compounds - pharmacology; flow cytometry; Half-Life; hepatocytes; histology; image analysis; Intralipid; intravenous injection; iron; iron oxides; Kupffer cells; Kupffer Cells - cytology; Kupffer Cells - metabolism; Labeling of immune cells; liver; Liver - cytology; Liver - metabolism; magnetic resonance imaging; Magnetite Nanoparticles; Male; monocytes; Nanoparticles; Phospholipids - pharmacokinetics; Phospholipids - pharmacology; pretreatment; Rats; Rats, Inbred BN; RES clearance; Soybean Oil - pharmacokinetics; Soybean Oil - pharmacology; PBS; r2; RES; Intralipid; FDA; MRI; Blood half-life; BN; ppm; USPIO; MPIO; RES clearance; Nanoparticles; FITC; PEG; ICP-MS; Labeling of immune cells