Associations between NBS1 polymorphisms, haplotypes and smoking-related cancers

• Published in: Carcinogenesis (New York) Vol. 31; no. 7; pp. 1264 - 1271
• Main Authors: Park, Sungshim L., Bastani, Delara, Goldstein, Binh Y., Chang, Shen-Chih, Cozen, Wendy, Cai, Lin, Cordon-Cardo, Carlos, Ding, Baoguo, Greenland, Sander, He, Na, Hussain, Shehnaz K., Jiang, Qingwu, Lee, Yuan-Chin A., Liu, Simin, Lu, Ming-Lan, Mack, Thomas M., Mao, Jenny T., Morgenstern, Hal, Mu, Li-Na, Oh, Sam S., Pantuck, Allan, Papp, Jeanette C., Rao, Jianyu, Reuter, Victor E., Tashkin, Donald P., Wang, Hua, You, Nai-Chieh Y., Yu, Shun-Zhang, Zhao, Jin-Kou, Zhang, Zuo-Feng
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2010
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Case-Control Studies; Cell Cycle Proteins - genetics; Female; Haplotypes; Humans; Linkage Disequilibrium; Lung Neoplasms - etiology; Lung Neoplasms - genetics; Male; Medical sciences; Middle Aged; Molecular Epidemiology; Neoplasms - etiology; Neoplasms - genetics; Nuclear Proteins - genetics; Polymorphism, Single Nucleotide; Smoking - adverse effects; Tobacco, tobacco smoking; Toxicology; Tumors; Association; Genetic variability; Tobacco smoking; Genotype; Malignant tumor; Haplotype; Cancer; Polymorphism

Constituents of tobacco smoke can cause DNA double-strand breaks (DSBs), leading to tumorigenesis. The NBS1 gene product is a vital component in DSB detection and repair, thus genetic variations may influence cancer development. We examined the associations between NBS1 polymorphisms and haplotypes...