Metal complexes as a promising source for new antibiotics

• Published in: Chemical science (Cambridge) Vol. 11; no. 1; pp. 2627 - 2639
• Main Authors: Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G, Baker, Murray, Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher, Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed M, Massi, Massimiliano, Moat, John, Mohamed, Heba A, Renfrew, Anna K, Rutledge, Peter J, Sadler, Peter J, Todd, Matthew H, Willans, Charlotte E, Wilson, Justin J, Cooper, Matthew A, Blaskovich, Mark A. T
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 14.03.2020
• Subjects: Antibiotics; Antimicrobial agents; Chemistry; Cobalt; Coordination compounds; Iridium; Malaria; Organic chemistry; Platinum; Silver; Toxicity; Zinc

There is a dire need for new antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classes of antibiotics are urgently required. Metal complexes are currently in...