Vascular Effects of Proteinase-Activated Receptor 2 Agonist Peptide

• Published in: Journal of vascular research Vol. 34; no. 4; pp. 267 - 272
• Main Authors: Emilsson, Kjell, Wahlestedt, Claes, Sun, Miao-kun, Nystedt, Sverker, Owman, Christer, Sundelin, Johan
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.07.1997; S. Karger AG
• Subjects: Amino Acid Sequence; Animals; Antihypertensive Agents; Biological and medical sciences; Blood Pressure - drug effects; Blood vessels and receptors; Cardiac and Cardiovascular Systems; Clinical Medicine; Fundamental and applied biological sciences. Psychology; Heart Rate - drug effects; In Vitro Techniques; Kardiologi; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Molecular Sequence Data; Nitric Oxide Synthase - antagonists & inhibitors; Peptide Fragments - chemistry; Peptides - pharmacology; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptors, Cell Surface - agonists; Receptors, Cell Surface - physiology; Research Paper; Vasodilation - drug effects; Vertebrates: cardiovascular system; Vascular endothelium; Proteinase-activated receptor 2; Nitric oxide; Hypotension; Vasodilation; Rat; Enzyme; Rodentia; Endothelium; Peptidases; Vasomotricity; Vertebrata; Membrane receptor; Mammalia; Arterial hypotension; Blood vessel; Hydrolases; Blood pressure; Circulatory system; Hemodynamics

Proteinase-activated receptor 2 (PAR-2) is a G protein-coupled receptor related to the thrombin receptor. PAR-2 can be activated by trypsin and by synthetic peptides corresponding to the new amino terminus generated by activating proteolytic cleavage. We show in this report that intravenous injectio...