CD1d Endosomal Trafficking Is Independently Regulated by an Intrinsic CD1d-Encoded Tyrosine Motif and by the Invariant Chain

• Published in: Immunity (Cambridge, Mass.) Vol. 15; no. 6; pp. 897 - 908
• Main Authors: Jayawardena-Wolf, Jayanthi, Benlagha, Kamel, Chiu, Ya-Hui, Mehr, Ramit, Bendelac, Albert
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2001
• Subjects: Amino Acid Motifs; Animals; Antigen Presentation - physiology; Antigens, CD1 - chemistry; Antigens, CD1 - genetics; Antigens, CD1 - metabolism; Antigens, CD1d; Antigens, Differentiation, B-Lymphocyte - physiology; Antigens, Surface - metabolism; B-Lymphocytes - metabolism; Biotinylation; CD1d antigen; Cell Membrane - metabolism; Cells, Cultured - metabolism; Dendritic Cells - metabolism; Endoplasmic Reticulum - metabolism; endosomes; Endosomes - metabolism; Evolution, Molecular; Fibroblasts - metabolism; Glycosylation; Histocompatibility Antigens Class II - physiology; Hybridomas - metabolism; Kinetics; Lymphoma, B-Cell - pathology; Lysosomes - metabolism; Mice; Microscopy, Fluorescence; Protein Binding; Protein Processing, Post-Translational; Protein Transport; Recombinant Fusion Proteins - metabolism; Subcellular Fractions - metabolism; Transfection; Tumor Cells, Cultured - metabolism; tyrosine; Tyrosine - chemistry

Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the en...