Zirconium oxide ceramic foam: a promising supporting biomaterial for massive production of glial cell line-derived neurotrophic factor

• Published in: Journal of Zhejiang University. B. Science Vol. 15; no. 12; pp. 1013 - 1022
• Main Authors: Liu, Zhong-wei, Li, Wen-qiang, Wang, Jun-kui, Ma, Xian-cang, Liang, Chen, Liu, Peng, Chu, Zheng, Dang, Yong-hui
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 01.12.2014; Springer Nature B.V
• Subjects: Activation; Animals; Astrocytes - cytology; Astrocytes - metabolism; Biocompatible Materials - chemistry; Biomaterials; Biomedical and Life Sciences; Biomedical materials; Biomedicine; Biomedicine & Biotechnology; Cell Proliferation; Cell Survival; Cells, Cultured; Ceramics; Ceramics - chemistry; Culture Media - chemistry; Enzyme-Linked Immunosorbent Assay; Foams; Glial Cell Line-Derived Neurotrophic Factor - biosynthesis; Microscopy, Electron, Scanning; Parkinson Disease - metabolism; Porosity; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction; Surgical implants; Zirconium - chemistry; Zirconium dioxide; Zirconium oxides; 陶瓷泡沫; Zirconium oxide; Ceramic foam; Glial cell line-derived neurotrophic factor (GDNF); 氧化锆; 帕金森病; Q819; Parkinson’s disease

This study investigated the potential application of a zirconium oxide (ZrO 2 ) ceramic foam culturing system to the production of glial cell line-derived neurotrophic factor (GDNF). Three sets of ZrO 2 ceramic foams with different pore densities of 10, 20, and 30 pores per linear inch (PPI) were pr...